发明名称 |
Methods and compositions for modulating notch activity |
摘要 |
<p>Provided herein are polypeptides and derivatives thereof that contain sequences of a Serrate protein and that inhibit Notch pathway function. Also provided herein are nucleic acids that encode the polypeptides, vectors and cells for producing the polypeptides, and related pharmaceutical compositions and kits. Additionally provided are antibodies which bind to the Notch inhibitory region of a Serrate protein. Therapeutic methods are also provided.</p> |
申请公布号 |
AU2012375337(A1) |
申请公布日期 |
2014.10.16 |
申请号 |
AU20120375337 |
申请日期 |
2012.03.29 |
申请人 |
ARTAVANIS-TSAKONAS, SPYRIDON;FLEMING, ROBERT |
发明人 |
FLEMING, ROBERT J.;ARTAVANIS-TSAKONAS, SPYRIDON |
分类号 |
A61P35/00;A61K39/395;C07K14/00 |
主分类号 |
A61P35/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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