METHODS FOR SELECTING AND TREATING CANCER IN PATIENTS WITH IGF-1R/IR INHIBITORS

摘要

The present invention relates generally to the field of pharmacogenomics, and more specifically to methods and procedures to determine drug sensitivity in patients to allow the identification of individualized genetic profiles which will aid in selecting cancer patients that are responsive to IGF-1R/IR inhibition.

主权项

1. A method for predicting the likelihood a patient will respond therapeutically to a cancer treatment comprising the administration of an IGF-1R/IR inhibitor, comprising the steps of:
(a) measuring the copy number of IRS2 in a sample from said patient, and (b) predicting an increased likelihood said patient will respond therapeutically to said cancer treatment if said patient has an increased or elevated IRS2 copy number.