发明名称 |
STABLE SOLID FORMS OF REGADENOSON |
摘要 |
<p>A process for the preparation of the amorphous form of Regadenoson of formula (I) is disclosed together with new crystalline polymorphic forms E, F and G and methods for their preparation. Regadenoson amorphous form can be prepared in mild reaction conditions with high chemical purity (>99.6%) and high stability to the heating. A particularly thermodynamically stable anhydrous crystalline form of Regadenoson (form G) is also disclosed, provided with high stability not when exposed to 90% RH at 25°C for 96 hour, but also to the heating up to 200°C.</p> |
申请公布号 |
WO2014167046(A1) |
申请公布日期 |
2014.10.16 |
申请号 |
WO2014EP57247 |
申请日期 |
2014.04.10 |
申请人 |
EUTICALS SPA |
发明人 |
GRISENTI, PARIDE;SHAHRZAD REZA, ELAHI;GUAZZI, GIUSEPPE;ARGESE, MARIA |
分类号 |
C07H19/167 |
主分类号 |
C07H19/167 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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