| 摘要 |
The present invention provides a compound, that is a 1-[(2-{[(alkyl or aryl)methyl]oxy}halo or haloalkyl substituted-phenyl)alkyl]-5-hydrocarbyl or substituted hydrocarbyl-1H-pyrazole carboxylic acid or alkylenylcarboxylic acid or a hydrocarbyl or substituted hydrocarbyl sulfonamide of said carboxylic acid or said alkylenylcarboxylic acid, provided however said compound is not a 3-carboxylic acid, a sulfonamide thereof, or a 3-methylenylcarboxylic acid. The compound may be represented by the following formula;Wherein R1, R2, R3, R4, R5, R6, X, W, X and Y are as defined in the specification. The compounds may be administered to treat DP1, FP, EP1, TP and/or EP4 receptor mediated diseases or conditions. |
| 主权项 |
1. A compound having the following formula wherein R1 is selected from the group consisting of OR7, N(R7)2, and N(R7)SO2R7 wherein R7 is selected from the group consisting of H, alkyl and aryl, wherein said alkyl and aryl may be substituted with fluoro; R2 is selected from the group consisting of H and alkyl; R3 is selected from the group consisting of H and alkyl; wherein R2 and R3 together can form a cycloalkyl ring; X is (CH2)n wherein n is 0 or an integer of from 1 to 3; provided however that when n is 0 or 1, R1 is not OR7; R4 is selected from the group consisting of H, alkyl and fluoroalkyl; R5 is selected from the group consisting of H, hydroxy, alkyl, aryl, alkoxy, aryloxy, halogen, nitro, amino, cyano, hydroxy, halogen, nitro, amino and cyano-substituted alkyl, aryl, alkoxy or aryloxy; R6 is selected from the group consisting of H, hydroxy, alkyl, aryl, alkoxy, aryloxy, halogen, nitro, amino, cyano, hydroxy, halogen, nitro, amino and cyano-substituted alkyl, aryl, alkoxy and aryloxy; Z is (CH2)m wherein m is 0 or an integer of from 1 to 3; Y is selected from the group consisting of O, S, SO, SO2 and (CH2)p, wherein p is 0 or an integer of from 1 to 3; and W is selected from the group consisting of alkyl, aryl, benzylyl and halogen-substituted benzyl. |
