| 发明名称 | Vaccinia virus mutants containing the major genomic deletions of MVA | ||
| 摘要 | The present invention provides modified vaccinia virus (VACV) genomes as well as vectors, especially viral vectors comprising the same. The present invention further provides modified vaccinia viruses. The present invention further provides methods for determining the effect of mutations in VACV with regard to competence for replication in certain cell types. The present invention further provides methods of preparing modified vaccinia viruses. | ||
| 申请公布号 | US8859257(B2) | 申请公布日期 | 2014.10.14 |
| 申请号 | US201113575773 | 申请日期 | 2011.01.28 |
| 申请人 | Bavarian Nordic A/S | 发明人 | Hausmann Jürgen;Meisinger-Henschel Christine;Suter Mark |
| 分类号 | C12N7/00;C12N15/863;C12N15/70;C12N15/64;C12N1/21;C12N5/10;C12Q1/70;C12N7/02;C12N15/86;A61K39/00 | 主分类号 | C12N7/00 |
| 代理机构 | Law Office of Salvatore Arrigo and Scott Lee, LLP | 代理人 | Law Office of Salvatore Arrigo and Scott Lee, LLP |
| 主权项 | 1. A method of preparing a chorioallantois vaccinia virus Ankara deletion variant (dCVA), said method comprising: (a) providing a vector comprising the genome of chorioallantois vaccinia virus Ankara (CVA); (b) deleting the sequences corresponding to del I, del II, del III, del IV, del V, and del VI of modified vaccinia Ankara virus (MVA); and (c) isolating the dCVA. | ||
| 地址 | Kvistgaard DK | ||