| 摘要 |
Disclosed herein are compounds of formula (I):;
or pharmaceutically acceptable salts thereof, wherein X1, L, Rx, Ry, Rz, A, m, n, p, q, s, and positions a and b are as defined in the specification. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also disclosed. |
| 主权项 |
1. A compound of formula (I):or a salt thereof, wherein:
L is a bond or CH2, and is bound to any one of the carbon atom of the monocyclic ring containing X1; X1 is O; n is 1 or 2; A is CH; m is 0, 1, or 2; Rx, at each occurrence, represents an optional substituent on any substitutable carbon atom of the ring containing A and each Rx is independently alkyl, halogen, haloalkyl, OH, O(alkyl), O(haloalkyl), NH2, N(H)(alkyl), or N(alkyl)2; p is 0, 1, or 2; Ry, at each occurrence, represents an optional substituent on any substitutable carbon atom of the ring containing X1 and each Ry is independently alkyl, haloalkyl, —(C1-C6 alkylenyl)-O(alkyl), G1, and —(C1-C6 alkylenyl)-G1; wherein G1, at each occurrence, is independently an aryl, optionally substituted with 1, 2, 3, or 4 substituents independently selected from the group consisting of alkyl, halogen, haloalkyl, O(alkyl), and O(haloalkyl); two Ry groups that are attached to the same carbon atom, together with said carbon atom to which they are attached, optionally form a C3-C6 monocyclic cycloalkyl ring, wherein the monocyclic cyclcoalkyl ring is optionally substituted with 1, 2, or 3 substituents independently selected from the group consisting of alkyl, oxo, halogen, and haloalkyl; s is 0 or 1; The alphabets a and b on the bicyclic ring independently represent the positions at which the —NH— of the urea moiety and a carbon atom of the ring are bound to each other, provided that when s is 1, the binding position for —NH— is at position a; and when s is 0, the binding position for —NH— is at position b; Rz, at each occurrence, represents an optional substituent on any substitutable position of the bicyclic ring and is independently halogen, haloalkyl, or alkyl; and q is 0 or 1. |
