| 发明名称 |
BROADLY NEUTRALIZING HUMAN ANTIBODY THAT RECOGNIZES THE RECEPTOR-BINDING POCKET OF INFLUENZA HEMAGGLUTININ |
| 摘要 |
The invention features a novel influenza antibody that specifically binds to influenza hemagglutinin and reduces or inhibits hemagglutinin binding to sialic acid. The invention also provides methods, compositions, and kits featuring the novel antibody and its use in preventing or treating influenza infection. |
| 申请公布号 |
US2014302043(A1) |
申请公布日期 |
2014.10.09 |
| 申请号 |
US201414171322 |
申请日期 |
2014.02.03 |
| 申请人 |
Duke University ;Children's Hospital Boston |
发明人 |
Whittle James;Harrison Stephen C.;Haynes Barton F.;Liao Hua-Xin;Moody M. Anthomy;Kepler Thomas B.;Schmidt Aaron G. |
| 分类号 |
C07K16/10;A61K38/02;A61K31/713;A61K51/10;A61K47/48 |
主分类号 |
C07K16/10 |
| 代理机构 |
|
代理人 |
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| 主权项 |
1. An isolated anti-influenza antibody or antibody fragment that specifically binds to an epitope of an influenza hemagglutinin (HA) and thereby reduces or inhibits influenza hemagglutinin binding to sialic acid. |
| 地址 |
Durham NC US |
