发明名称 |
MODIFIED CASPASE POLYPEPTIDES AND USES THEREOF |
摘要 |
The technology relates in part to compositions comprising modified caspase-9 polypeptides, compositions comprising nucleic acids coding for modified caspase-9 polypeptides, chimeric modified caspase-9 polypeptides, and methods of use thereof, including methods for cell therapy. Methods for cell therapy include modifying transfused cells to express an inducible modified caspase-9 protein, with reduced basal activity in the absence of the inducer. |
申请公布号 |
CA2903216(A1) |
申请公布日期 |
2014.10.09 |
申请号 |
CA20142903216 |
申请日期 |
2014.03.07 |
申请人 |
BELLICUM PHARMACEUTICALS, INC. |
发明人 |
SPENCER, DAVID;CHANG, WEI-CHUN |
分类号 |
C12N9/64;A61K35/17;A61P35/00;A61P37/06;C12N5/0783;C12N5/10;C12N15/57;C12N15/62;C12N15/85;C12N15/86;C12Q1/00 |
主分类号 |
C12N9/64 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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