发明名称 |
MACROCYCLIC HOPO CHELATORS |
摘要 |
The present invention provides a novel class of macrocyclic compounds of formula (I) as well as complexes formed between a metal (e.g., lanthanide) ion and the compounds of the invention. Preferred complexes exhibit high stability as well as high quantum yields of lanthanide ion luminescence in aqueous media without the need for secondary activating agents. Preferred compounds comprise hydroxypyridinonyl moieties within their macrocyclic structure and are characterized by surprisingly low, non-specific binding to a variety of polypeptides such as antibodies and proteins as well as high kinetic stability.
(I) |
申请公布号 |
EP2470513(B1) |
申请公布日期 |
2014.10.08 |
申请号 |
EP20100812556 |
申请日期 |
2010.08.24 |
申请人 |
LUMIPHORE, INC. |
发明人 |
BUTLIN, NATHANIEL, G.;RAYMOND, KENNETH, N.;XU, JIDE;D'ALEO, ANTHONY |
分类号 |
G01N33/533;C07D487/18;C07D498/22 |
主分类号 |
G01N33/533 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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