| 主权项 |
1. An isolated antibody that binds to human Axl, wherein the antibody binds human Axl with an affinity of ≦600 pM, wherein the antibody binds mouse Axl with an affinity of ≦1 nM, and wherein the antibody comprises (a) HVR-H1 comprising GFX1X2X3GX4WIH, wherein X1 is T or S, X2 is F or L, X3 is T or S, X4 is H, S or T (SEQ ID NO:118); (b) HVR-H2 comprising GWIX1PYX2X3X4X5YYADSVKG, wherein X1 is S, N or A; X2 is G, R or S; X3 is G or R; X4 is S, Y or H; X5 is T, A or P (SEQ ID NO:119); (c) HVR-H3 comprising AREYX1X2WX3X4SX5X6GYX7MDY, wherein X1 is S, N or P; X2 is G or D; X3 is G, R, or A; X4 is G or S; X5 is S or Y; X6 is V or I; X7 is A or E (SEQ ID NO:120); (d) HVR-L1 comprising RASQDVSTAVA (SEQ ID NO:10); (e) HVR-L2 comprising SASFLYS (SEQ ID NO:11); and (f) HVR-L3 comprising QQSYX1X2X3X4T, wherein X1 is T, S or Y; X2 is T, N, S or F; X3 is P or R; X4 is P, Y or S (SEQ ID NO:121). |
