Anti-CD154 antibodies having impaired FcR binding and/or complement binding properties

摘要

Improved anti-CD154 antibodies are provided herein which have ablated FcR binding. The use of these antibodies for inducing tolerance and treating immune diseases including autoimmunity, inflammation and allergic disorders is disclosed herein.

主权项

1. A human or humanized anti-CD154 antibody of the IgG1 isotype, wherein the Fc region of said antibody comprises an E269R mutation and a K322A mutation, wherein said mutations respectively eliminate FcR binding and C1Q binding.