| 发明名称 |
Compositions and methods for treating cancer |
| 摘要 |
A method of treating a cancer with an mTOR inhibitor and an anti-IGF-1 R antibody is disclosed. |
| 申请公布号 |
US8852590(B2) |
申请公布日期 |
2014.10.07 |
| 申请号 |
US201013264060 |
申请日期 |
2010.04.06 |
| 申请人 |
Merck Sharp & Dohme Corp.;Ariad Pharmaceuticals, Inc. |
发明人 |
Sathyanarayanan Sriram;Winter Christopher;Klinghoffer Richard |
| 分类号 |
A61K39/395;A61P35/00;A61K31/4353 |
主分类号 |
A61K39/395 |
| 代理机构 |
|
代理人 |
Su Li;Ginkel Laura M. |
| 主权项 |
1. A method of treating breast cancer with an mTOR inhibitor and an anti-IGF-1R antibody, wherein the mTOR inhibitor is ridaforolimus and the anti-IGF-1R antibody comprises a light chain comprising the amino acid sequence SEQ ID NO: 8 and a heavy chain comprising the amino acid sequence of SEQ ID NO: 10, wherein the ridaforolimus is orally administered at a dose of 10 mg or 20 mg per day five days a week and the antibody is administered intravenously at a dose of 10 mg/kg either once a week or once every other week. |
| 地址 |
Rahway NJ US |
