| 主权项 |
1. An oral care composition having a pH of 8.5-10, comprising a compound of formula A: wherein the compound of Formula A is a compound of Formula (I) wherein R* and R* * are independently substituted or unsubstituted aralkyl, substituted or unsubstituted aryl, substituted or unsubstituted cycloalkyl, or substituted or unsubstituted heterocycle; z is 0 or 1, with the proviso, that if z is 1, then A is CR10 or N, and D is N or CR12, and with the further proviso that if z is 0 then D is O, S or NR12a; E is hydrogen, hydroxy, alkoxy, (cycloalkyl)oxy, (cycloheteroalkyl)oxy, carboxy, or alkyloxycarbonyl; m is 0 or 1; R12 is hydrogen, hydroxyalkyl, aminoalkyl, alkylaminoalkyl, dialkylaminoalkyl, carboxy, alkyloxycarbonyl, amido, hydroxy, alkoxy, aryloxy, thio, alkylthio, arylthio, alkylsulfonyl, dialkylaminosulfonyl, alkylaminosulfonyl, aminosulfonyl, sulfo, cyano, halo, nitro, amino, dialkylamino, alkylamino, arylamino, diarylamino, aralkylamino, or diaralkylamino; R12a is hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted aralkyl, substituted or unsubstituted aryl, substituted or unsubstituted cycloalkyl, or substituted or unsubstituted heterocycle; and R9 and R10 are independently hydrogen, alkyl, cycloalkyl, hydroxyalkyl, aminoalkyl, alkylaminoalkyl, dialkylaminoalkyl, halo, carbonyl, hydroxyimino, carboxy, alkyloxycarbonyl, alkylthio, alkylsulfonyl, arylthio, dialkylaminosulfonyl, alkylaminosulfonyl, aminosulfonyl, amino, alkoxy, nitro, sulfo, or hydroxy; in free or pharmaceutically acceptable salt form. |
