| 主权项 |
1. A compound having structural formula I:or a pharmaceutically acceptable salt or a tautomer thereof, wherein:
each R4 is independently selected from —C(O)N(R2)(R2), —C1-C4 alkyl, —CN, —(C0-C4 alkylene)-N(R2)(R2), —O—(C1-C4 alkylene)-O—(C1-C3 alkyl), —(C1-C4 alkylene)-O—(C1-C3 alkyl), and —O—(C0-C4 alkylene)-(R1), wherein R1 is selected from —C1-C4 alkyl and heterocyclyl; each R2 is independently selected from hydrogen and unsubstituted C1-C4 alkyl each R6 is independently selected from —C1-C4 alkyl or two R6 bound to the same carbon atom are taken together to form oxo, or two R6 bound to different carbon atoms are taken together to form methylene, ethane-1,2-diyl, or propane-1,2-diyl forming a ring that is bridged to the piperazine-1,4-diyl portion of the compound; each R8 is independently selected from halo, —OH, —N(R2)(R2), C1-C4 alkyl, and —O—(C1-C4 alkyl); L is selected from a bond, —(C1-C4 alkylene)-, —O—, —S—, —SO2—, —N(R2)—, —O—(C1-C4 alkylene)-, —(C1-C4 alkylene)-O—, —(C1-C4 alkylene)-N(R2)—, —N(R2)—(C1-C4 alkylene)-, —N(R2)—CO—(C1-C4 alkylene)-, —CO—N(R2)—(C1-C4 alkylene)-; n is 0, 1, 2, or 3; m is 0, 1, 2, 3, or 4; p is 0, 1, or 2; q is 0, 1, 2, or 3; ring A is monocyclic or bicyclic aryl, heteroaryl, carbocyclyl or heterocyclyl; each R10 is independently selected from halo, —OH, —CN, —C(O)N(R2)(R2), C1-C4 alkyl, —O—(C1-C4 alkyl), and heterocyclyl, or two R1° bound to adjacent ring carbon atoms are taken together to form methylenedioxy; wherein unless otherwise specified any alkyl, or alkylene portion of the compound is optionally substituted; and wherein the compound is not |
