| 发明名称 |
LIPID COMPOSITIONS FOR NUCLEIC ACID DELIVERY |
| 摘要 |
The present invention provides apparatus and processes for producing liposomes. By providing a buffer solution in a first reservoir, and a lipid solution in a second reservoir, continuously diluting the lipid solution with the buffer solution in a mixing chamber produces a liposome. The lipid solution preferably comprises an organic solvent, such as a lower alkanol. |
| 申请公布号 |
US2014294937(A1) |
申请公布日期 |
2014.10.02 |
| 申请号 |
US201414304578 |
申请日期 |
2014.06.13 |
| 申请人 |
PROTIVA BIOTHERAPEUTICS, INC. |
发明人 |
MacLachlan Ian;Jeffs Lloyd;Palmer Lorne R.;Giesbrecht Cory |
| 分类号 |
A61K9/127;A61K47/10;A61K47/24 |
主分类号 |
A61K9/127 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A lipid vesicle comprising:
a messenger RNA (mRNA); a cationic lipid; an amphipathic lipid; and a polyethyleneglycol (PEG)-lipid, wherein the mRNA is fully encapsulated in the lipid vesicle. |
| 地址 |
Burnaby CA |
