| 发明名称 |
MITIGATION AND REVERSAL OF FIBROSIS AND INFLAMMATION BY INHIBITION OF TL1A FUNCTION AND RELATED SIGNALING PATHWAYS |
| 摘要 |
The invention relates to methods of treating fibrosis and inflammatory bowel disease. In one embodiment, the present invention treats gut inflammation by administering a therapeutically effective dosage of TL1A inhibitors and/or DR3 inhibitors to an individual. In another embodiment, the present invention provides a method of reversing tissue fibrosis in an individual by inhibiting TL1A-DR3 signaling function. |
| 申请公布号 |
CA2908553(A1) |
申请公布日期 |
2014.10.02 |
| 申请号 |
CA20142908553 |
申请日期 |
2014.03.27 |
| 申请人 |
CEDARS-SINAI MEDICAL CENTER |
发明人 |
SHIH, DAVID Q.;TARGAN, STEPHAN R.;LI, DALIN;BILSBOROUGH, JANINE |
| 分类号 |
A61K38/12;A61K38/16;C12Q1/68 |
主分类号 |
A61K38/12 |
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