| 发明名称 |
NOVEL INHIBITORS OF MAMMALIAN TIGHT JUNCTION OPENING |
| 摘要 |
The present invention provides novel peptides that inhibit and/or reduce the opening of mammalian tight junctions, i.e. peptide tight junction antagonists. The present invention also provides methods for the treatment of excessive or undesirable permeability of a tissue by administering to a subject suffering from such a condition a composition comprising a peptide tight junction antagonist of the invention. |
| 申请公布号 |
US2014296130(A1) |
申请公布日期 |
2014.10.02 |
| 申请号 |
US201414305418 |
申请日期 |
2014.06.16 |
| 申请人 |
Alba Therapeutics Corporation |
发明人 |
Tamiz Amir |
| 分类号 |
C07K7/06;A61K38/06;A61K38/08;C07K5/10;A61K38/07;C07K5/08;A61K45/06 |
主分类号 |
C07K7/06 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A peptide tight junction antagonist, wherein the peptide comprises an amino acid sequence selected from the group consisting of SEQ ID NOs: 2-69. |
| 地址 |
Baltimore MD US |
