Methods of decorating hydroxyapatite biomaterials with modular biologically active molecules

摘要

A modular peptide design strategy wherein the modular peptide has two functional units separated by a spacer portion is disclosed. More particularly, the design strategy combines a hydroxyapatite-binding portion and a biomolecule-derived portion. The modular peptides have improved non-covalent binding to the surface of the HA-based materials, and are capable of initiating osteogenesis, angiogenesis, and/or osteogenic differentiation.

主权项

1. A method of coating a biomaterial with a modular peptide, the method comprising: exposing a biomaterial to a phosphate buffered saline (PBS) solution comprising a modular peptide, the modular peptide comprising a hydroxyapatite-binding portion comprising an amino acid sequence selected from the group consisting of SEQ ID NO:1, SEQ ID NO:2, SEQ ID NO:3, SEQ ID NO:4, SEQ ID NO:5, and SEQ ID NO:6, a spacer portion, and a biomolecule-derived portion.