Polycondensation of lactic acid for medical biodegradable polylactic acid catalyzed by creatinine

摘要

A direct polycondensation method for medical biodegradable polylactic acid (PLA). The invention uses commercialized creatinine (a type of biomaterial organic guanidine compounds—the arginine metabolite creatinine in human body) as the catalyst and industrial lactic acid (mass content 85-90%, aqueous solution) as the monomer to synthesize the PLA in terms of second polycondensation without solvent. Instead of tin catalysts having cytotoxicity, the catalyst used in the invention has high biocompatibility and biosafety. The synthesized PLA does not contain any metal and other toxic components; therefore, it can be used as the carrier for targeting drugs and controlled release drugs. The green catalyst and green processing method (no solvent applied and no toxic products produced) are used to synthesize the green biodegradable PLA with high biosafety. The molecular weight distribution for all synthesized products is narrow and the molecular weight is controllable within 1.5-3.0×104.

主权项

1. A method of polycondensing polylactic acid comprising:
a. subjecting a reaction vessel containing an 85-90 mass % aqueous solution of lactic acid to a vacuum and filling the vessel with argon, b. repeating step (a) three times, c. with argon remaining in the vessel, heating to 130-150° C. to dehydrate the lactic acid for 1-6 hours, d. reducing the vessel pressure to 100 Torr to dehydrate at 130-150° C. for 1-6 hours, e. reducing the vessel pressure to 30 Torr to dehydrate at 130-150° C. for 1-6 hours to form n moles of oligomers of lactic acid having 5-8 lactic acid repeat units, f. adding 0.001 n to 0.01 n moles of creatinine to the reaction vessel, and g. reducing the vessel pressure to 10 Torr and heating to 150-190° C. for 48-96 hours to produce the polylactic acid.