| 摘要 |
Provided are compounds which generally have a triketone structure. Examples of the compounds include derivatives of 1,3-cyclohexanedione, such as: 1,3-cyclohexanedione, 2-propanoyl-5-cyclohexyl-; 1,3-cyclohexanedione, 2-propanoyl-5-[4-fluorophenyl]-; 1,3-cyclohexanedione, 2-acetyl-5-[thien-2-yl]-; 1,3-cyclohexanedione, 2-acetyl-5-butyl-; and 1,3-cyclohexanedione, 2-propanoyl-5-[bicyclo[2.2.1]hept-2-en-5-yl]-. The compounds can be used to alter the lifespan of eukaryotic organisms and treat inflammation. |
| 主权项 |
1. A pharmaceutical composition comprising a compound with the following structure: wherein R1 and R2 are independently
an aliphatic alkyl group having 1 carbon to 8 carbons, wherein the aliphatic alkyl group is branched, saturated or has one or more carbon-carbon multiple bonds, and is, optionally, substituted with one or more halogens,a cyclic alkyl group having 3 carbons to 8 carbons, wherein the cyclic alkyl group is saturated or has one or more carbon-carbon multiple bonds, and is, optionally, substituted with one or more alkyl groups having 1 carbon to 6 carbons,an aryl group, wherein the aryl group has a single, multiple-ring or fused-ring structure, and each ring is, optionally, independently substituted with one or more groups selected from halogen, hydroxy, alkoxy group having 1 carbon to 6 carbons (wherein if the compound is substituted with two adjacent alkoxy groups the groups are, optionally, linked by an alkyl group having 1 carbon to 4 carbons), amino group, alkylamino group having one alkyl group or two alkyl groups, wherein each alkyl group has 1 carbon to 6 carbons, arylamino group having one aromatic group or two aromatic groups, wherein each aryl group has 4 carbons to 6 carbons, alkyloxy group, wherein the alkyl group has 1 carbon to 6 carbons and is linear, branched or cyclic, and aryloxy group, wherein the aryl group has 4 carbons to 6 carbons,an aralkyl group, wherein the araalkyl group is attached via the aliphatic moiety having 1 carbon to 8 carbons and an aromatic moiety having 4 carbons to 8 carbons, ora heterocyclic group having 3 carbons to 8 carbons, wherein the heterocyclic group is saturated or comprises one or more carbon-carbon multiple bonds, and R3 is an optional substitution and is any of the R1 and R2 groups. |
