Method for the diffusion of molecules which are insoluble in an aqueous medium and composition using said method

摘要

A process for local permucosal diffusion of amino acid salts of low dosage lipophlic non-steroidal anti-inflammatory or anti-mycotic molecules for an aqueous medicine for the treatment of bucco-pharyngeal ailments is disclosed. Compositions and tablets implementing this diffusion process are also disclosed.

主权项

1. A method for locally treating buccopharyngeal ailments in a subject in need thereof, comprising:
providing a composition comprising a non-steroidal anti-inflammatory drug (NSAID) in a water-soluble lysine-salt form, said composition being in tablet form, and comprising 2.5 wt % or less of the NSAID; orally and locally administering the composition to the subject; and allowing the composition to solubilize in the buccopharyngeal cavity of the subject, the composition being solubilized by the saliva of the subject, the lysine dissociating from the NSAID thereby imparting a lipophilic property to the NSAID, and said lipophilic NSAID actively diffusing through mucous tissues in the buccopharyngeal cavity of the subject without recrystallizing.