发明名称 |
IMMUNOASSAYS AND METHODS OF DETECTING AND MEASURING INTACT FIBROBLAST GROWTH FACTOR 23, AND C-TERMINAL AND N-TERMINAL FRAGMENTS THEREOF |
摘要 |
Immunoassays and methods for detecting and quantifying biological levels of intact fibroblast growth factor (FGF)-23, as well as the N-terminal and C-terminal fragments thereof in a biological sample. The relative amounts or ratios of FGF-23 relative the N-terminal and C-terminal fragments can also be determined. The systems and methods deploy antibodies that are specific to antigenic regions formed upon either the N-terminal or C-terminal regions of FGF-23 and are systematically applied such that intact FGF-23 and the fragments thereof can be detected and quantified. In certain embodiments, dissimilar labels conjugated to tracer antibodies or labeled antibodies specific to N-terminal and/or C-terminal tracer antibodies are utilized to facilitate detection and quantification of both whole length FGF-23 and any fragments thereof. |
申请公布号 |
WO2014150818(A1) |
申请公布日期 |
2014.09.25 |
申请号 |
WO2014US24315 |
申请日期 |
2014.03.12 |
申请人 |
LAVIGNE, JEFFREY;ZAHRADNIK, RICHARD;LZZ MANAGEMENT COMPANY, INC. |
发明人 |
LAVIGNE, JEFFREY;ZAHRADNIK, RICHARD |
分类号 |
G01N33/53;G01N33/00;G01N33/543;G01N33/566 |
主分类号 |
G01N33/53 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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