| 发明名称 |
COVALENT INHIBITORS OF KRAS G12C |
| 摘要 |
Irreversible inhibitors of G12C mutant K-Ras protein are provided. Also disclosed are methods to modulate the activity of G12C mutant K-Ras protein and methods of treatment of disorders mediated by G12C mutant K-Ras protein. |
| 申请公布号 |
CA2904393(A1) |
申请公布日期 |
2014.09.25 |
| 申请号 |
CA20142904393 |
申请日期 |
2014.03.14 |
| 申请人 |
ARAXES PHARMA LLC |
发明人 |
REN, PINGDA;LIU, YI;LI, LIANSHENG;FENG, JUN;WU, TAO |
| 分类号 |
C07D213/74;C07D211/56;C07D211/58;C07D231/40;C07D237/04;C07D285/16;C07D401/04;C07D401/12;C07D403/04;C07D403/06;C07D405/06;C07D419/12;C07D471/04;C07D487/04;C07D487/10 |
主分类号 |
C07D213/74 |
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