发明名称 |
An improved process for preparation of physiologically active polypeptide complex |
摘要 |
<p>Disclosed is a method for the preparation of a complex in which a physiologically active polypeptide is covalently bonded to an immunoglobulin constant region via a non-peptidyl linker. The method is characterized by the employment of a reducing agent, by which conventional problems of low production yield and modification of the polypeptide can be overcome. The physiologically active polypeptide-non-peptidyl polymer-immunoglobulin constant region complex can be produced with high purity and yield as well as at low cost. Thus, the method is industrially useful. Moreover, by exhibiting a prolonged action profile, the physiologically active polypeptide-non-peptidyl polymer-immunoglobulin constant region complex can be effectively used for developing long-acting formulations of physiologically active polypeptides which have improved drug compliance.</p> |
申请公布号 |
AU2013228144(A1) |
申请公布日期 |
2014.09.25 |
申请号 |
AU20130228144 |
申请日期 |
2013.03.08 |
申请人 |
HANMI SCIENCE CO., LTD. |
发明人 |
JANG, MYUNG HYUN;KIM, MIN YOUNG;LEE, JONG-SOO;KIM, DAE JIN;BAE, SUNG MIN;KWON, SE CHANG |
分类号 |
C07K19/00;A61K47/48;C07K1/10 |
主分类号 |
C07K19/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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