| 发明名称 | Methods and compositions for anti-EGFR treatment | ||
| 摘要 | In some embodiments, the present invention provides methods for enhancing the sensitivity of cancer cells to anti-EGFR treatment, wherein the method comprises the introduction of a miR-200 miRNA to the cancer cells. In other embodiments, the present invention provides methods for treating cancer by exposing the cancer cells to an anti-EGFR composition after the above-mentioned enhancement step. In other embodiments, the present invention provides methods for assessing and enhancing the sensitivity of cancer cells to anti-EGFR treatment. In various other embodiments, the present invention provides compositions and expression vectors for practicing the afore-mentioned methods. | ||
| 申请公布号 | US8841273(B2) | 申请公布日期 | 2014.09.23 |
| 申请号 | US201013504696 | 申请日期 | 2010.10.28 |
| 申请人 | Board of Regents, The University of Texas System | 发明人 | Adam Liana;Dinney Colin P.;McConkey David J. |
| 分类号 | C12N15/11;C12N15/113 | 主分类号 | C12N15/11 |
| 代理机构 | Parker Highlander PLLC | 代理人 | Parker Highlander PLLC |
| 主权项 | 1. A method of treating a patient having cancer that is resistant to EGFR treatment using anti-EGFR treatment, said method comprising the steps of administering to cells of said cancer an amount of a miR-200 miRNA that is effective to render said cancer sensitive to anti-EGFR treatment; and treating said patient with an anti-EGFR composition. | ||
| 地址 | Austin TX US | ||