| 主权项 |
1. A compound of Formula (III):or a pharmaceutically acceptable salt thereof;wherein
R1 and R2, taken in combination with the N to which they are attached, form a saturated, unsaturated or aromatic heterocyclic ring having 0, 1, or 2 additional ring heteroatorms independently selected from N, O, and S and which heterocyclic ring has from 4 to 7 total ring atoms, said heterocycle having 0, 1, 2, or 3 substituents which are independently selected from C1-C4alkyl, haloC1-C4alkyl, C2-C4alkenyl, C2-C4alkynyl, hydroxyl, C1-C4alkoxy, haloC1-C4alkoxy, amino, mono- and di-C1-4alkylamino, aminoC1-C4alkyl, C1-C4alkanoylaminoC1-C4alkyl; R3 is C1-C6alkyl or C2-C6alkenyl; R4 is C1-C8alkyl, C3-C8cycloalkyl, or saturated 5 or 6 membered heterocyclic ring having 1 or 2 ring heteroatoms independently selected from N, O and S, each of which is substituted with 0-2C1-C4 alkyl groups; J is a bond or a divalent residue of the formula: R5 is C1-C8alkyl, C3-C8cycloalkyl, or saturated 5 or 6 membered heterocyclic ring having 1 or 2 ring heteroatoms independently selected from N, O and S, each of which is substituted with 0-2C1-C4 alkyl groups; R6 is hydrogen or C1-C4alkyl; E is a bond, CH2, C(O), S(O)2, C(R9)2C(O), or C(O)C(R9)2, R9 is independently selected at each occurrence from hydrogen and C1-C4alkyl; X is absent or selected from NR11a or oxygen; i and k are independently selected integers selected from the group consisting of 0, 1, 2, 3 and 4; j is an integer selected from the group consisting of 1, 2, 3 and 4, wherein the sum of i+j+k is less than or equal to 5 and greater than or equal to 2 when X is absent and the sum of i+j+k is less than or equal to 4 and greater than or equal to 1 when X is oxygen; R11 represents zero to three residues each independently selected at each occurrence from the group consisting of halogen, hydroxy, amino, C1-4alkyl, C3-6cycloalkyl, C1-4alkoxy, mono- and di-C1-4alkylamino, hydroxyC1-4alkyl, and C1-4alkoxyC1-4alkyl; and R11a is independently selected at each occurrence from the group consisting of hydrogen, C1-4alkyl, haloC1-4alkyl, C3-6cycloalkyl, hydroxyC1-4alkyl, and C1-4alkoxyC1-4alkyl. |
