Compuestos derivados de acidos carboxilicos de carbamoil-hidroisoquinolinas sustituidas, inhibidores de proteinas antiapoptoticas bcl-xl; composicion farmaceutica; metodo de tratamiento para el cancer de mama, cancer de cuello uterino, cancer colorrectal, cancer hepatocelular, cancer de esofago, leucemias, mielomas, entre otros.

摘要

Disclosed are compounds of formula (I) which inhibit the activity of anti-apoptotic Bcl-xL proteins, compositions containing the compounds and methods of treating diseases during which Bcl-xL proteins are expressed, eg cancer. X is heteroaryl; Y1 is phenylene or heteroarylene; L1 is a linker; Y2 is cycloalkyi, cycloalkenyl, heterocycloalkyl or heterocycloalkenyl; Z1 is C(0)OR9, C(O)NR10R11, C(0)R11, NR10C(O)R11, etc.