BICYCLIC ANALGESIC COMPOUNDS

摘要

Analgesic compounds for treatment of pain or fever, comprising a bicyclopentane moiety linked to an amine, combinations of the compounds with opioid analgesic drugs, and methods for treating pain or fever by administering the compounds.

主权项

1. A compound of Formula 1: wherein R1 is H, —CH3, CF3, or a substituted or unsubstituted (C2 to C5) lower alkyl; R2 is H or C(═Y)R4; R3 is H, F, D, hydroxy, (C1 to C10)alkoxy, (C1 to C30) substituted or unsubstituted alkyl, aryl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, cycloalkynyl, heterocycle, heteroaryl, arylalkyl, alkylaryl, heteroarylalkyl, or —(C═O)L; R4 is CF3 or (C1 to C10) substituted or unsubstituted lower alkyl; Y is S or O; and —(C═O)L is a hydrolyzable prodrug ester leaving group.