PEPTIDES COMPRISING NON-NATURAL AMINO ACIDS AND METHODS OF MAKING AND USING THE SAME
摘要
This invention relates to novel compositions comprising analogs of naturally occurring polypeptides, wherein the analog comprises an α-amino acid and at least one &bgr;-amino acid. Administration of the compositions may be used for effecting treatment or prevention of a plurality of disease states caused by dysfunctional biochemical or biological pathways. The compositions and methods of this invention are particularly useful to identify novel therapeutic modulators of in-vivo receptor activity with extended half-lives and relevant bioactivity as compared to the naturally translated polypeptides upon which the analogs are derived.
申请公布号
WO2014145718(A2)
申请公布日期
2014.09.18
申请号
WO2014US30527
申请日期
2014.03.17
申请人
LONGEVITY BIOTECH, INC.;SHANDLER, SCOTT;GELLMAN, SAMUEL H.;GLEDHILL, JOHN M.
发明人
SHANDLER, SCOTT;GELLMAN, SAMUEL H.;GLEDHILL, JOHN M.