BIOCOMPATIBLE HYDROGEL POLYMER MATRIX FOR DELIVERY OF CELLS

摘要

Provided herein are biocompatible hydrogel polymer matrices, which are prepared from biocompatible pre-formulations. The biocompatible pre-formulations comprise at least one nucleophilic compound, at least one electrophilic compound, and at least one cell. The biocompatible hydrogel polymer matrix is bioabsorbable and releases the cell at a target site, achieving a controlled delivery. The biocompatible hydrogel polymer matrix provides a solid support conducive for cell viability and functionality. The cells may grow on the hydrogel polymer surface of inside the hydrogel polymer matrix.

主权项

1. A fully synthetic, polyglycol-based biocompatible hydrogel polymer matrix comprising a fully synthetic, polyglycol-based biocompatible hydrogel polymer comprising at least one first monomeric unit bound through at least one amide, thioester, or thioether linkage to at least one second monomeric unit, wherein the polymer forms the matrix that encapsulates:
(a) at least one cell; and (b) a culture medium which supports the growth of the at least one cell; andwherein the fully synthetic, polyglycol-based biocompatible hydrogel polymer matrix provides controlled release of the at least one cell, when implanted at a target site in an animal's body, to the target site of the animal's body.