| 主权项 |
1. A compound of Formula I: wherein: R1 is
(a) phenyl, optionally substituted with zero to four groups selected from the group consisting of: halo, C1-C4alkyl, alkoxy, perhaloalkyl and perhaloalkoxy; or(b) heteroaryl, selected from the group consisting of: wherein Rk is selected from the group consisting of: H, halo, C1-C3alkyl and alkoxy;Rj is selected from the group consisting of: H, C1-C3alkyl optionally substituted with halo, OH and alkoxy; andn is an integer from 0-3;X is N or CR2;R2 is H, perhaloalkyl or C1-C3 lower alkyl; R3 is H, perhaloalkyl, C1-C4 alkyl, alkalkoxy, CH2Ri, —C(O)Re or phenyl; wherein phenyl is optionally substituted with zero to two groups selected from the group consisting of: halo, C1-C3alkyl, alkoxy, perhaloalkyl and perhaloalkoxy;
Ri is OH, OC1-C3 alkyl, NC3H6, N(C1-C3alkyl)2 or halo;Re is OH, OC1-C3 alkyl, N(C1-C3alkyl)2, or NC3H6;R4 and R5 are H or C1-C3 alkyl; and R8 is phenyl or pyridyl; optionally substituted with zero to four Rm substituents wherein Rm is selected from the group consisting of: halo, C1-C3alkyl, alkoxy, perhaloalkyl and perhaloalkoxy; or
R8 is selected from the group consisting of: and
pharmaceutically acceptable salts of compounds of Formula (I). |
