| 摘要 |
<p>Methods and systems are provided for determining susceptibility to 5-fluorouracil (5-FU) or capecitabine toxicity. Methods are provided for treating a human subject based on a determined susceptibility to 5-fluorouracil (5-FU) or capecitabine toxicity. Mild cognitive impairment, a common complaint of cancer patients treated with chemotherapy, is often referred to as "chemobrain." Mechanisms for cognitive impairment remain unknown, although investigators have proposed several hypotheses, including low efficiency efflux pumps, deficits in DNA repair, reduced antioxidant capacity, deregulation of the immune response, and reduced capacity for neural repair.</p> |
