Method for Improving the Efficacy of Curcuminoids and Their Analogs

摘要

The invention relates to a method for increasing the therapeutic efficacy of curcuminoids and analogs. More specifically, the invention relates to a method for increasing the therapeutic efficacy of systemically administered formulations that contain curcuminoids and the equivalent therapeutics thereof. The method is characterized in that together with the administration of the formulation the patient is irradiated with visible, and optionally ultraviolet, radiation during a treatment. The invention also relates to phototherapy devices that emit visible radiation over a surface area greater than 0.2 m2 with an irradiance of more than 2 mW/cm2, the devices being suitable for use in the treatment of proliferative diseases, particularly moderate-to-severe psoriasis or tumor processes.

主权项

1) A method of treating cancer or tumor, the method comprising:
a) systemically administering to a subject, having cancer or tumor, an effective amount of curcuminoid; b) exposing 0.2 m2 or greater or 40 cm2 or greater of skin of the subject to device-generated radiation having an irradiance of 2 mW/cm2 or higher to achieve a unit radiation dose of 1-36 J/cm2, wherein the radiation comprises visible light radiation and optionally further comprises ultraviolet light radiation; and c) repeating steps a) and b) until a cumulative radiation dose of 150 to 600 J/cm2 during a period is achieved.