Anti-ILT7 antibody

摘要

Abstract An antibody binding to IPC was obtained by using an animal cell in which a cell membrane protein associatable with ILT7 was co-expressed as an immunogen. The antibody of the invention has a high specificity which allows immunological distinction between other ILT family molecules and ILT7. The anti-ILT7 antibody of the invention bound to IPC and inhibited the activity thereof. With the anti-ILT7 antibody of the invention, the IPC activity can be inhibited and an interferon-related disease can be treated or prevented. ILT7 expressionismaintainedeveninIPCinthepresenceof IFNa. Therefore, an inhibitory action of IPC activity by the anti-ILT7 antibody can be expe cted even in an autoimmune disease patient with an increased production of IFNax.