| 发明名称 |
METHOD OF GENERATING TUMOR-SPECIFIC T CELLS |
| 摘要 |
A method for the expansion of tumor-specific T-cells includes obtaining an enriched population of T-cells from a subject with cancer; and contacting the enriched population of T-cells ex-vivo with: (i) an anti-CD3 antibody, an anti-CD28 antibody, and/or functional fragments thereof, and (ii) a VEGF inhibitor, to activate and expand the T-cells. |
| 申请公布号 |
US2014255368(A1) |
申请公布日期 |
2014.09.11 |
| 申请号 |
US201414205069 |
申请日期 |
2014.03.11 |
| 申请人 |
Case Western Reserve University |
发明人 |
Kim Julian;Graor Hallie;Zhang Mei;Visioni Anthony |
| 分类号 |
C12N5/0783 |
主分类号 |
C12N5/0783 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method for the expansion of tumor-specific T-cells, the method comprising:
obtaining an enriched population of T-cells from a subject with cancer; and contacting the enriched population of T-cells ex-vivo with: (i) an anti-CD3 antibody, an anti-CD28 antibody, and/or functional fragments thereof, and (ii) a VEGF inhibitor, at amounts effective to activate and expand the T-cells. |
| 地址 |
Cleveland OH US |
