发明名称 |
NANO-SUSPENSION PROCESS |
摘要 |
<p>Described herein is a process for preparing nano-suspensions, wherein the process comprises: providing an admixture of at least one active pharmaceutical compound, an aqueous dispersion medium, and milling media and applying thereto acoustic energy having a frequency of from about 10 hertz to 1000 hertz and which supplies a linear acceleration of from about 10 G′s to about 100 G′s (where“G”is the force of gravity) for a period sufficient to supply a nano-suspension having a D50 of less than about 1 micron, preferably less than about 500 nm. Described also are nano-suspensions having novel properties prepared via the inventive process.</p> |
申请公布号 |
EP2773323(A1) |
申请公布日期 |
2014.09.10 |
申请号 |
EP20120846357 |
申请日期 |
2012.10.26 |
申请人 |
MERCK SHARP & DOHME CORP. |
发明人 |
LEUNG, DENNIS;NELSON, TODD, D.;KWONG, ELIZABETH |
分类号 |
A61K9/00;A61K9/10;A61K9/14;A61K9/16;A61K31/192;A61K47/10;A61K47/26;A61K47/32;A61K47/38;B02C19/18 |
主分类号 |
A61K9/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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