MONOCLONAL ANTIBODY AGAINST HUMAN NON-SMALL-CELL LUNG CARCINOMA AND USE THEREOF

摘要

The invention discloses a monoclonal antibody against human non-small cell lung carcinoma and a use of the monoclonal antibody, belonging to the technical field of biotechnology. Also disclosed is a hybridoma cell strain NM001-1 secreting a monoclonal antibody against human non-small cell lung carcinoma, deposited in China Center for Type Culture Collection on August 31, 2011, CCTCC No.: C201172. Also disclosed is a monoclonal antibody NJ001-1 against human non-small cell lung carcinoma secreted by the hybridoma cell strain NM001-1. The monoclonal antibody NJ001-1 secreted by the hybridoma (CCTCC No.: C201172) has high yield and high titer, and has specific reactivity against lung adenocarcinoma and squamous carcinoma cell lines. Provided in the invention is a use of the monoclonal antibody NJ001-1 in preparing detection reagents for diagnosis of human non-small cell lung carcinoma. In vivo and in vitro research results show that the monoclonal antibody NJ001-1 has obvious inhibition effect on lung adenocarcinoma both in vivo and in vitro. Therefore, the monoclonal antibody may be applied in preparing drugs for treating human non-small cell lung carcinoma.