| 发明名称 |
INFLUENZA VACCINES INCLUDING COMBINATIONS OF PARTICULATE ADJUVANTS AND IMMUNOPOTENTIATORS |
| 摘要 |
Influenza vaccines containing insoluble particulate adjuvants have been found to elicit an IgG response that is primarily a TH2 response (IgG1). This response can be shifted towards a TH1 response (IgG2a) by including immunopotentiators in the compositions. Thus the invention provides an immunogenic composition comprising: (i) an influenza virus antigen; (ii) an insoluble particulate adjuvant; and (iii) a immunopotentiator. |
| 申请公布号 |
US2014248312(A1) |
申请公布日期 |
2014.09.04 |
| 申请号 |
US201414194525 |
申请日期 |
2014.02.28 |
| 申请人 |
NOVARTIS VACCINES AND DIAGNOSTICS SRL |
发明人 |
RAPPUOLI Rino;O'HAGAN Derek;DEL GIUDICE Giuseppe |
| 分类号 |
A61K47/02;A61K39/145 |
主分类号 |
A61K47/02 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. An immunogenic composition comprising: (i) an influenza virus antigen; (ii) an insoluble particulate adjuvant; and (iii) an immunopotentiator which comprises a TLR7 agonist. |
| 地址 |
Siena IT |
