发明名称 |
FREE PSA ANTIBODIES AS DIAGNOSTICS, PROGNOSTICS AND THERAPEUTICS FOR PROSTATE CANCER |
摘要 |
The present invention provides methods of monitoring and measuring tumor-associated free PSA (“fPSA”) with antibody polypeptides as an indication of androgen receptor signaling. In a particular embodiment, the methods may be used to assess the efficacy of anti-androgen and/or general anti-cancer treatments. The present invention also provides various methods and compositions relating to antibodies that are specific for tumor-associated or intratumoral fPSA. For example, the present invention provides compositions, including pharmaceutical compositions, comprising anti-fPSA antibodies, or fragments or characteristic portions thereof. The present invention further provides various therapeutic and/or diagnostic methods of using anti-fPSA antibodies and/or compositions. |
申请公布号 |
EP2771688(A1) |
申请公布日期 |
2014.09.03 |
申请号 |
EP20120844178 |
申请日期 |
2012.10.25 |
申请人 |
MEMORIAL SLOAN-KETTERING CANCER CENTER |
发明人 |
SAWYERS, CHARLES;ULMERT, DAVID;LEWIS, JASON;EVANS, MICHAEL;LIJA, HANS |
分类号 |
A61B5/00;A61K38/00;A61K39/395;A61K51/00;A61K51/10;G01N33/53;G01N33/574 |
主分类号 |
A61B5/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|