摘要 |
<p>A novel compound having an excellent NFºB inhibitory effect is provided. Specifically disclosed is a compound represented by the following formula (1) or a salt thereof:
wherein, R 1 represents a hydrogen atom, a lower alkyl group, or the like;
R 2 represents a hydrogen atom, a lower alkyl group, a halogen atom, or the like;
R 3 represents a hydrogen atom, a lower alkyl group, a hydroxyl group, or a halogen atom;
R 4 represents a hydrogen atom or a lower alkyloxy group;
R 5 represents a hydrogen atom, a lower alkyloxy group, a halogen atom, a hydroxyl group, or a methylenedioxy group formed together with R 6 or an isopropylidenedioxy group formed together with R 6 ;
R 6 represents a hydrogen atom, a lower alkyloxy group, or a methylenedioxy group formed together with R 5 or an isopropylidenedioxy group formed together with R 5 ;
R 7 represents a hydrogen atom or a lower alkyl group; and
R 8 represents a hydrogen atom, a hydroxyl group, an amino group, a lower alkylcarbonyloxy group, or a halogen atom.</p> |