| 发明名称 |
Albumin variants |
| 摘要 |
Variants of a parent albumin having altered plasma half-life compared with a parent albumin are described. Fusion polypeptides and conjugates including the variant albumin are also described. Embodiments include, but are not limited to, a polypeptide which is a variant of albumin, including one or more alterations at one or more positions corresponding to 104, 105, 106, 107, 108, 109, 110, 111, 112, 113, 114, 115, 116, 117, 118, 119 and 120 in SEQ ID NO: 2. |
| 申请公布号 |
US8822417(B2) |
申请公布日期 |
2014.09.02 |
| 申请号 |
US201213463944 |
申请日期 |
2012.05.04 |
| 申请人 |
Novozymes Biopharma DIC A/S |
发明人 |
Andersen Jan Terje;Dalhus Bjorn;Sandlie Inger;Cameron Jason;Plumridge Andrew;Friis Esben Peter;Delahay Karen |
| 分类号 |
A61K38/38;C07K14/765;C12N15/62;C12N15/14;A61P7/00;C12N15/63;C12N5/10;B82Y5/00 |
主分类号 |
A61K38/38 |
| 代理机构 |
|
代理人 |
Krenicky Michael W. |
| 主权项 |
1. A polypeptide which is a variant of albumin, comprising one or more alterations at one or more positions corresponding to 104, 106, 108, 109, 110, and 120 in SEQ ID NO: 2 with one or more of A, C, D, E, F, G, H, I, K, L, M, N, P, Q, R, S, T, V, W, Y. |
| 地址 |
Bagsvaerd DK |
