| 摘要 |
The present invention describes [1,2,4]thiadiazine 1,1-dioxide compounds and pharmaceutically acceptable salts thereof, which are useful in lowering serum uric acid in a patient in need thereof comprising administering to the patient a therapeutically or prophylactically effective amount of a [1,2,4]thiadiazine 1,1-dioxide compound. |
| 主权项 |
1. A method for lowering serum uric acid in a patient comprising administering to the patient a therapeutically effective amount of a compound of Formula IwhereinRing B isA isZ is —(CR11R12)n—,Y is —(CR13R14)m—,n is 1 or 2,m is 2 or 3,R1 is H, —NH2, or —(CH2)q—NH—S(O)2CH3, wherein q is 0 or 1,R2 is C1-C6 alkyl, C3-C6 cycloalkyl, aryl, or —(CH2)—R15, wherein R15 is wherein R16, R17, R18, R19 and R20 are independently H, C1-C6 alkyl, hydroxy, or halo, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, and R14 are independently H or C1-C6 alkyl, wherein each alkyl, cycloalkyl, or aryl are optionally substituted by one or more alkyl, hydroxyl, or halo substituents, or a pharmaceutically acceptable salt, hydrate, solvate, tautomer or stereoisomer thereof. |
