Methods for controlling SR protein phosphorylation, and antiviral agents whose active ingredients comprise agents that control SR protein activity

摘要

The present invention provides: (1) antiviral agents that act by reducing or inhibiting the activity of SR proteins, more specifically, (i) antiviral agents that act by enhancing dephosphorylation of SR proteins, and (ii) antiviral agents that act by inhibiting proteins that phosphorylate SR proteins; (2) antiviral agents that act by inhibiting the expression of SR proteins, and (3) antiviral agents that act by activating proteins that antagonize SR proteins. The present invention also provides compounds that inhibit SRPKs, which phosphorylate SR proteins. Such compounds inhibit the activity of SR proteins and have antiviral activities. Various new viruses including SARS have emerged, and thus the present invention provides long-lasting broad-spectrum antiviral agents applicable to new viruses.

主权项

1. A compound represented by the following formula (I):or a pharmaceutically acceptable salt or hydrate thereof;
wherein R1 represents a halogen atom; R2 represents a hydrogen atom; R3 represents a nitrogen-containing heterocycle which may have a substituent; R4 represents a hydrogen atom; Q represents —C(S)—; and W represents a group represented by the following formula (II): wherein R5 and R6, together with the adjacent nitrogen atom, form a heterocycle which may have a substituent.