Methods and Systems for Imaging Tissue Motion Using Optical Coherence Tomography

摘要

A system and method for measuring tissue motion within a living tissue of the anterior segment and aqueous outflow system of the eye in a subject are provided. Tissue movements are extracted from a plurality of images acquired from the living tissue using an optical coherence tomography system. The images may be corrected using motion compensation. To extract the tissue movements from the images, waves from a cardiac pulse or other externally induced pulses from the subject are acquired, and a pulse wave is defined for a given time, which is then correlated with a velocity wave defined for a velocity of tissue and/or fluid movement within the tissue region for the same given time. Pulsatile motion is then isolated in the tissue region from the plurality of images.

主权项

1. A method of measuring tissue motion within a living tissue of an anterior segment and an aqueous outflow system of an eye in a subject comprising:
extracting tissue motion from a plurality of images acquired from the living tissue using an optical coherence tomography system, wherein the extracting comprises:
acquiring waves induced by a cardiac pulse or other induced pulse waves from the subject;correcting the acquired images using motion compensation;determining, from the corrected images, a region for examination of the living tissue;defining a velocity wave for a velocity of motion within the region for examination for a given time;defining a pulse wave induced by the cardiac pulse from the subject for the given time;correlating the velocity wave and the pulse wave in the region for examination; andisolating pulsatile motion in the region for examination from the corrected acquired images.