发明名称 |
HYDANTOINS THAT MODULATE BACE-MEDIATED APP PROCESSING |
摘要 |
In certain embodiments hydantoin compounds are provided herein that are effective to inhibit BACE activity against APP. Without being bound to a particular theory, it is believed the activity of the hydantoins identified herein appears to be associated with binding to BACE and/or to APP particularly when these moieties form a BACE/APP complex. Accordingly, it is believed the compounds described herein represent a new class of compounds designated herein as APP-Binding-BACE Inhibitors (ABBIs) and provide a new mechanism to modulate APP processing. The hydantoins described herein appear to show improved brain permeability and functional BACE inhibition. |
申请公布号 |
WO2014127042(A1) |
申请公布日期 |
2014.08.21 |
申请号 |
WO2014US16100 |
申请日期 |
2014.02.12 |
申请人 |
BUCK INSTITUTE FOR RESEARCH ON AGING |
发明人 |
JOHN, VARGHESE;BREDESEN, DALE E. |
分类号 |
C07D233/88;A61K31/4166;A61P25/00;C07D233/70;C07D401/10 |
主分类号 |
C07D233/88 |
代理机构 |
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代理人 |
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地址 |
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