| 摘要 |
PROBLEM TO BE SOLVED: To provide a solid preparation containing an enteric solid dispersion rapidly dissolving a drug in the preparation without damaging the dissolution properties of the solid preparation, or a method for preparing the same. SOLUTION: The solid preparation comprising a soluble drug, an enteric polymer, an excipient and a disintegrator comprises a granular product wherein a mixed powder comprising at least the excipient and the disintegrator is partly or entirely covered with the solid dispersion comprising a hardly soluble drug and the enteric polymer. The invention provides the solid preparation in which the release of the hardly soluble drug in the stomach is suppressed so that the dissolution rate of the hardly soluble drug using the Japanese Pharmacopoeia first liquid (artificial gastric fluid) after 120 minutes elapse is 10 mass% or less of the initial concentration of the drug administered, or a method for producing the same. COPYRIGHT: (C)2013,JPO&INPIT |
