Dose distribution modeling by region from functional imaging

摘要

Functional imaging information is used to determine a probability of residual disease given a treatment. The functional imaging information shows different characteristic levels for different regions of the tumor. The probability is output for planning use and/or used to automatically determine dose by region. Using the probability, the dose may be distributed by region so that some regions receive a greater dose than other regions. This distribution by region of dose more likely treats the tumor with a same dose, allows a lesser dose to sufficient treat the tumor, and/or allows a greater dose with a lesser or no increase in risk to normal tissue. The dose plan may account for personalized tumors as each patient may have distinct tumors. Probability of dose application accuracy may also be used, so that a combined treatment probability allows efficient dose planning.

主权项

1. A system for modeling dose distribution, the system comprising:
an input operable to receive functional imaging information representing metabolic or biochemical activity of a tumor; a processor operable to apply a model of tumor response to a treatment dose, the tumor response being different for different regions of the tumor as a function of the functional imaging information, wherein the model represents a probability of residual disease after treatment in each of the different regions given the functional imaging information; and a display operable to output an image as a function of the tumor response.