Synthetic methods and intermediates for the preparation of xenicanes

摘要

The invention provides novel synthetic intermediates and synthetic methods that are useful for preparing compounds of the xenicane family. Certain compounds of the invention may also possess anti-cancer properties.

主权项

1. A compound of formula 1: wherein:
Ra is H, (C1-C6)alkyl, (C2-C6)alkenyl, (C2-C6)alkynyl, (C3-C8)cycloalkyl, (C3-C8)cycloalkyl(C1-C6)alkyl, aryl, or heteroaryl, wherein each (C1-C6)alkyl, (C2-C6)alkenyl, (C2-C6)alkynyl, (C3-C8)cycloalkyl, and (C3-C8)cycloalkyl(C1-C6)alkyl of Ra is optionally substituted with one or more groups independently selected from halo, hydroxy, cyano, nitro, (C1-C6)alkoxy, (C3-C8)cycloalkyl, oxo, carboxy, aryl, aryloxy, and —NRbRc; and wherein each aryl, and heteroaryl of Ra is optionally substituted with one or more groups independently selected from (C1-C6)alkyl, halo, hydroxy, cyano, carboxy, nitro, trifluoromethyl, trifluoromethoxy, (C1-C6)alkoxy, (C1-C6)alkoxycarbonyl, (C1-C6)alkanoyloxy, and —NRbRc; andRb and Rc are each independently selected from H, (C1-C6)alkyl, (C3-C8)cycloalkyl, (C3-C8)cycloalkyl(C1-C6)alkyl, aryl, heteroaryl, aryl(C1-C6) alkyl and heteroaryl(C1-C6)alkyl; or Rb and Rc together with the nitrogen to which they are attached form a aziridino, azetidino, morpholino, piperazino, pyrrolidino or piperidino.