发明名称 |
GENERATION OF FUNCTIONAL DENDRITIC CELLS |
摘要 |
<p>Nanoparticles containing a photosensitizer configured to generate a reactive oxygen species when exposed to an appropriate wavelength of light can be used to enhance immunogenicity of cancer cells, such as breast cancer cells. Such enhanced immunogenicity cancer cells, or supernatants thereof, can be used to activate dendritic cells or cause dendritic cells to produce INF-gamma. Nanoparticles having mitochondria-targeting moieties are more effective at enhancing the immunogenicity of the cancer cells, or causing the dendritic cells to produce IFN-gamma, than nanoparticle lacking mitochondria-targeting moieties or free photosensitizer.</p> |
申请公布号 |
WO2014124425(A1) |
申请公布日期 |
2014.08.14 |
申请号 |
WO2014US15744 |
申请日期 |
2014.02.11 |
申请人 |
UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. |
发明人 |
DHAR, SHANTA;MARRACHE, SEAN;HARN, DONALD, A.;TUNDUP, SMANLA |
分类号 |
G01N33/551;G01N33/50;G01N33/574 |
主分类号 |
G01N33/551 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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