IMPROVED BACULOVIRAL EXPRESSION SYSTEM AND METHODS OF PRODUCING THE SAME

摘要

The present invention is based on the discovery that large parts of the genome of nucleopolyhedtovirus (NPV)-alpha baculovirus clade la viruses can be deleted with out deleterious effect on the usability of the virus comprising such genome in the infection of cells in cell culture. Accordingly, the present invention provides NPY-alpha baculovirus clade la genome which is reduced in size in comparison to the respective native NPV-alpha baculovirus clade la genome, such genomes comprising heterologous nucleotides, viruses comprising either of these genomes, cells infected with such viruses and methods for producing such viruses and cells.